The liver has a unique structure, especially at the level of individual cells. Hepatocytes, the main liver cells, release ...

Existing tissue-derived liver organoid models consist of only one cell type and fail to replicate the complex cellular composition and tissue architecture, such as the liver periportal region.

Drug-induced liver injury (DILI) is a frequent cause of acute liver failure and drug withdrawals. Liver organoids, as a ...

As a second model, the team introduced the top risk mutation for fatty liver disease into their organoid system using prime editing. In the third model, the researchers modeled genetic lipid ...

Different genetic mutations underlie different degrees of aggressiveness Artegiani and Hendriks constructed the liver organoid models by modifying the protein kinase A (PKA) using CRISPR-Cas9.

So, if scientists hope to create self-growing patches of liver organoid tissue that could help repair damaged organs, it's important that the lab-grown tissue faithfully reproduce such zones.

The team cultured liver cells known as hepatocytes in a dish and looked for free glycans. They also analyzed free glycans in ...

This provides us with a source of unlimited material to do any type of type of experiment. We started modeling cancer mutations using liver organoids ... but they also blocked organoid proliferation, ...

Studying turtle genetics with a liver organoid should speed up research ... "From a single chunk of tissue, you can have an unlimited source of experiment subjects and don't have to sample animals ...

New tissue-derived organoid model: A next-generation organoid model, composed of three liver cell types – adult hepatocytes, cholangiocytes, and liver mesenchymal cells – reconstructs the liver ...

Thanks to this technique we were able to study this tumor type." Artegiani and Hendriks constructed the liver organoid models by modifying the protein kinase A (PKA) using CRISPR-Cas9. PKA is a ...

Studying turtle genetics with a liver organoid should speed up research to uncover the ... “From a single chunk of tissue, you can have an unlimited source of experiment subjects and don’t have to ...