eLife36s
In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins
(C) Immunoprecipitation of the endogenous Squ from ovarian lysate revealed the interaction with Spn-E protein. Proteins were detected by western blotting analysis using the specific antibody for each ...
eLife36s
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
The compelling evidence explains how Rab8 family members bind at two sites to allosterically regulate MICAL1, and relieve an auto-inhibited state unable to bind actin. This study lays the basis for ...
eLife49m
Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors
Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States This important study employed multiple orthogonal techniques and ...
eLife50m
Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage
This important work advances our understanding of DNA methylation and its consequences for susceptibility to DNA damage. This work presents evidence that DNA methylation can accentuate the genomic ...
eLife1h
TET2 contributes to gluconeogenesis and pathology of type 2 diabetes
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China ...